5 edition of Sustained Release Theophylline in the Treatment of Chronic Reversible Airways Obstruction found in the catalog.
Sustained Release Theophylline in the Treatment of Chronic Reversible Airways Obstruction
by Excerpta Medica
Written in English
|Contributions||J. H. G. Jonkman (Editor), J. W. Jenne (Editor), F. E. R. Simons (Editor)|
|The Physical Object|
|Number of Pages||197|
The aim of this multi-centre, double blind, randomised, controlled trial (DBRCT) is to assess the effect of low dose theophylline, singly and in combination with low dose oral prednisone, on COPD (Chronic Obstructive Pulmonary Disease) exacerbations, quality of life and secondary clinical outcomes compared with usual therapy and placebo over 48 weeks of treatment. – A chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Reversible airflow obstruction + ++ + Airway inflammation + ++ + + ‐Sustained‐release theophylline. Step 3 Treatment for Adults and Children > 5: Moderate Persistent Controller –Preferred DailyFile Size: 2MB.
Airflow obstruction due to chronic bronchitis or emphysema; most patients have features of both. Obstruction. Is progressive. May be accompanied by airway hyperreactivity. May be partially reversible. Chronic bronchitis is characterized by excessive mucous secretions with productive cough for 3 months or more in at least 2 consecutive years. In international guidelines, theophylline has been relegated to third-line therapy in COPD ().Theophylline is still used as a bronchodilator, but inhaled anticholinergics and β 2-agonists are preferred therapy (3, 4).Theophylline tends to be added to these inhaled bronchodilators for patients with more severe disease and has been shown to give additional clinical improvement when added to a Cited by: 6.
Chronic obstructive pulmonary disease (COPD) causes enormous distress and generates immense cost worldwide. The problem is growing, particularly in the third world, and it has been predicted that COPD will become the third most common cause of mortality in the world in As the major cause of COPD is tobacco smoking, it is of utmost importance that scientific societies all over the world Cited by: 9. Theophylline has been used for several decades in the treatment of reversible airway obstruction. Due to its nar-row therapeutic window, theophylline still remains an important cause of intoxication . Intoxication may re-sult from either acute ingestion or chronic use. The spec-trum of clinical toxicity after theophylline poisoning var.
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Sustained release theophylline in the treatment of chronic reversible airways obstruction: international workshop, Mont Ste Marie, Canada. theophylline sustained-release - oral, Uniphyl. chronic bronchitis).
Theophylline belongs to a class of drugs known as xanthines. It works in the airways by relaxing muscles, opening air passages to improve breathing, and decreasing the lungs' response to irritants.
Controlling symptoms of breathing problems can decrease time lost from work. Theophylline is used in the treatment of patients with reversible airways obstruction (asthma and chronic obstructive lung disease). Modes of Administration. Theophylline is normally administered orally as a modi-fied-release preparation.
Theophylline can also be given in the form of an ethylenediamine salt (aminophylline) orally or rarely. Sustained-release theophylline reduces dyspnea in nonreversible obstructive airway disease. Mahler DA, Matthay RA, Snyder PE, Wells CK, Loke J.
Although orally administered theophylline has been prescribed widely in patients with nonreversible airway obstruction, symptomatic benefit Cited by: Book reviews Book reviews M. CUSHLEY Sustained Release Theophylline in the Treatment of CRAO, Ed.
by J.H.G. Jonkman, J.W. Jenne & F.E.R. Simons. Excerpta Medica, Pp. This book summarizes a international workshop held in Canada on sustained release theophylline preparations in chronic reversible airways obstruction. Theophylline was demonstrated to be the active ingredient in those combinations and a dose-response effect from theophylline was apparent.
The indications for theophylline in the treatment of asthma and recommendations for its safe use will be discussed here. Overviews of the treatment of acute and chronic asthma are provided elsewhere. Treatment of reversible chronic airways obstruction with doxofylline compared with slow-release theophylline: A double-blind, randomized, multicentre trial Article Feb 1.
Author(s): Jonkman,J H G; Jenne,J W; Simons,F E R Title(s): Sustained release theophylline in the treatment of chronic reversible airways obstruction.
Peter J. Barnes, in Asthma and COPD (Second Edition), Introduction. Theophylline remains one of the most widely prescribed drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, since it is inexpensive and widely available. In many industrialized countries, however, theophylline has become a third-line treatment that is only used in poorly.
Theophylline is an orally acting xanthine that has been used since for the treatment of respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD).Author: Peter J Barnes.
Theophylline is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize logically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral.
COPD treatment: The treatment of acute COPD with theophylline IV is not supported or recommended by current clinical practice guidelines due to significant side effects (GOLD ). Patients who have not received theophylline in the previous 24 hours: mg/kg/dose IV (preferred route) or 5 mg/kg orally (immediate release only [oral solution])/ Theophylline (1,3-dimethylxanthins) can indirectly stimulate both β1 and β2 receptors through release of endogenous catecholamines.
It is used for the treatment of pulmonary conditions, including asthma and chronic obstructive pulmonary disease (COPD). Learn theophylline with free interactive flashcards. Choose from 97 different sets of theophylline flashcards on Quizlet.
For the treatment of acute exacerbations† of reversible airways obstruction (including status asthmaticus) in patients who are not responding to first-line therapies. NOTE: Although reference texts continue to list this indication, several studies have failed to demonstrate a benefit of theophylline in the management of acute bronchospasm.
Theophylline extended-release tablets are indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis. In another study of COPD patients, where reversible airways obstruction was carefully excluded, theophylline decreased dyspnea to a small and significant degree but did not alter exercise performance.
5 x 5 Mahler, DA, Matthay, RA, Snyder, PE, Wells, CK, and Loke, J. Sustained-release theophylline reduces dyspnea in non-reversible obstructive Cited by: Chronic obstructive pulmonary disease 1. or sustained release theophylline in the previous 24 e theophylline in the previous 24 hrs. SpirometrySpirometry FEV1 should be measured before a bronchodilator is 1 should be measured before a bronchodilator is given.
The bronchodilator should be given by metered dose inhaler. Describe a treatment plan for the patient with stable COPD and for the patient with an acute exacerbation. If present, send for PFTs to demonstrate reversible airways obstruction •Sustained release theophyllineFile Size: 9MB.
Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth.
muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., nonbronchodilator prophylactic effects). While the mechanisms of action of theophylline are not known. Start studying Pharmacology chapter 6, 7, & 8.
Learn vocabulary, terms, and more with flashcards, games, and other study tools. explains when theophylline could be used as a treatment of chronic obstructive pulmonary disease (COPD).
After administering a sustained release form of theophylline, serum blood levels should be measured.Rivington R.N., Calcutt L., Stewart J.H. () Comparison of Once-Daily Uniphyl to Twice-Daily Sustained-Release Theophylline in Elderly Patients with Chronic Airflow Obstruction.
In: Dethlefsen U., Matthys H. (eds) Fokus — Atemwegserkrankungen : R. N. Rivington, L. Calcutt, J. H. Stewart.Comparison of Two Sustained‐Release Theophylline Preparations in Adult Patients With Obstructive Airways Disease. Dr. Paul S. Harkaway MD. Corresponding Author. Department of Internal Medicine, Ann Arbor, Ml.
Balfour, Apt. 1, Harper Woods, MI Search for more papers by this by: 3.